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The Prostate: Its Function and Diseases
The prostate is a gland of the male reproductive system about the size and shape of a walnut. Located in front of the rectum, it wraps around the urethra (the tube that carries urine from the bladder out through the tip of the penis). The Prostate's main function is to produce fluid for semen, which transports sperm.
Chances are, if you are visiting this site . . .
You or someone you know is suffering from a prostate problem.
The most common symptoms include:
- difficulty initiating urination
- weak urinary stream
- frequent urination
- often with urgency
- often accompanied with incontinence
- waking several times at night to urinate
- sexual dysfunction and decreased libido
The most common conditions are:
- benign prostatic hyperplasia (BPH)
- prostate cancer
BPH (benign prostatic hyperplasia aka benign prostatic hypertrophy) is a non-cancerous enlargement of the prostate, which often causes urinary dysfunction. As can be seen in the cross section image above, an enlarged prostate squeezes and narrows the section of the urethra, that runs through the prostate, resulting in restricted urinary flow, as well as other related symptoms.
BPH is the most common prostate disease and is more common among older men, because as a man ages, his body normally produces more of certain hormones. Starting at about age 40, levels of a hormone called prolactin begin increasing in men, which stimulates an increased production of the enzyme 5-alpha reductase. This in turn increases the metabolism of testosterone, resulting in a lower blood level of testosterone as well as an increase in the metabolic byproduct DHT (di-hydro-testosterone). DHT is very unhealthy and has the undesirable effect of stimulating prostate cells into dividing and multiplying, which causes the prostate to enlarge.
More than 50 percent of men age 60, and 80 percent of men age 80, are estimated to suffer from BPH. It is important to note that BPH does not necessarily lead to cancer; however, a man can have BPH and cancer at the same time.
Prostatitis is an inflammation of the prostate. It is not contagious. Postatitis is a mysterious ailment and most urologists will admit that, though in some cases they do understand its cause, many times they do not. Prostatitis is sometimes caused by bacteria similar to those which cause other types of urinary infections. Some patients however, have no evidence of bacteria in their prostates yet are thought to carry microorganisms such as Chlamydia or Ureaplasma, which are harder to identify by standard culture techniques. Still other patients have no evidence of any microorganisms at all. This makes it very difficult to diagnose and treat. Many urologists will "blindly" prescribe antibiotics, which seldom work, It is important to note that prostatitis sometimes develops from untreated BPH.
Prostate cancer is a malignant tumor that most often begins in the outer part of the prostate. As the tumor grows, it may spread to the inner part of the prostate. Treatment options for prostate cancer include watchful waiting, hormonal therapy, radiation, brachytherapy and surgery.Read Less
DRE and PSA Tests
Digital Rectal Exam (DRE) and Prostate-Specific Antigen (PSA) are two tests commonly used to detect men at higher risk of prostate cancer and other prostate diseases.
The DRE is a physical examination performed by a physician, who puts on a latex glove, asks you to bend over and inserts his finger up your rectum till he reaches your prostate. The doctor then evaluates the prostate by it's size and texture. In this way, the doctor can assess if the prostate is enlarged and/or if there is any abnormal growth on the surface. The DRE is a somewhat subjective test and not all that reliable in determining if a prostate is marginally enlarged or not. It is more reliable in diagnosing a grossly enlarged prostate, and can be quie useful in detecting any suspicious prostate lesions, that could potentially be cancer.
The PSA is a blood test and is also quite limited as well. It measures the blood level of PSA, a protein that is produced by the prostate gland. The results are usually reported as nanograms of PSA per milliliter (ng/mL) of blood. A high PSA can indicate a greater chance of developing prostate cancer. However, a high PSA does not necessarily mean cancer is present; many men with BPH may also have elevated PSA levels.
There is no specific normal or abnormal level of PSA in the blood. In the past, most doctors considered PSA levels of 4.0 ng/mL and lower as normal. However, because the PSA test may give false-positive or false-negative results, today many doctors consider the change in PSA score to be more important than the score itself.
Some advisory groups now recommend against the use of the PSA test to screen for prostate cancer.
To quote Richard Ablin Ph.D., the man who discovered the Prostate Specific Antigen (PSA) molecule, "I never dreamed that my discovery four decades ago would lead to such a profit-driven public health disaster," and Thomas Stamey, M.D., an early proponent of PSA screening (published in the Journal of Urology in 2004), "The PSA era is over in the USA."
In light of these comments, one wonders with good cause, as to whether a man should even rely on the PSA test for prostate cancer screening anymore. After all, you can get a false positive, which would cause you needless worry and concern, or you can get a false negative, which would give you a false sense of relief. Both of these false conclusions are bad.
If you have a PSA test and find the number elevated, think before you take the next step. Retest, and have your doctor conduct a PCA3 and a 4K score (there are other exams such as a 3D-color Doppler Ultrasound), before jumping into the "sheep dip" of treatment protocols that the majority of men who are left impotent and incontinent, live to regret.Read Less
Symptom Testing Standards
In order for scientists around the world to evaluate the efficacy of a particular therapy, certain testing standards have been established. One of the most common standards is the International Prostate Symptom Score (IPSS). The score is stated as a number that can range from 0 to 35, depending on the severity of lower urinary tract symptoms. The International Prostate Symptom Score also includes a scoring of quality of life as it relates to urinary symptoms.
A measurement to assess the strength of the urinary stream is called the maximum urinary flow rate (Qmax). The maximum urinary flow is commonly decreased with benign prostate disease such as BPH (benign prostatic hyperplasia).
The third test is the amount of residual urine that remains in the bladder after voiding, or post-void residual urine (PVR). This is most easily assessed with pre- and post-void ultrasounds of the bladder.Read Less
- Almost 30 million men suffer from benign prostatic hypertrophy (BPH).
- Odds are 2 to 1 you'll have prostate problems by the time you are 60.
- Each year over 400,000 men in the United States alone undergo prostate surgery; and over a billion dollars a year is spent on prostate treatment.
- Surgery often results in incontinence and impotence.
- Proscar, the leading pharmaceutical drug for treating prostate problems, is highly dangerous; and according to the U.S. Veteran's Administration is no more effective than sugar pills.
- Despite it's popularity, saw palmetto does not support prostate health, because it has a low concentration of beta sitosterol.
Prostate Miracle®Advanced Formula . . .
prostate support (with NO side effects).
- Prostate Miracle® Advanced Formula combines the 4 most important natural nutrients for promoting prostate health (in the correct amounts to be supportive): 300 mg of Beta-Sitosterol with 7.5 mg of Zinc, 35 mcg of Selenium and 1000 iu's of Vitamin D3.
- Beta Sitosterol is THE most extensively studied prostate health supporting supplement.
- Prostate Miracle® Advanced Formula contains 3,000 times more beta sitoeterol than saw palmetto.
- Prostate Miracle® Advanced Formula contains GMO free, pine based, phytosterol complex (imported from France), guaranteed to be 99% pure and contain NOT less than 70% beta sitosterol.
- Prostate Miracle® Advanced Formula is manufactured in the USA, in GMP Certified, FDA licensed and inspected facilities.
Prostate Miracle® Advanced Formula: Supplement Facts
|Serving Size: 1 Capsule
Servings per container: 60
|Amount Per 2 Servings||% Daily Value|
Phytosterol Complex (from non GMO Pine)
|Vitamin D3 (as cholecalciferol)||2,000 iu's||500%|
|Zinc (as Zinc Citrate)||15 mg||100%|
|Selenium (as Albion® Selenium Glycinate Complex)||70 mcg||100%|
Other ingredients: 100% Vegetable capsule, L-Leucine
Take one capsule in the morning and one in the evening.
Beta-Sitosterol and Prostate Health
Beta-sitosterol is the miraculous common denominator found in saw palmetto, pygeum africanum, pumpkinseed oil and stinging nettles. The concentration of beta sitosterol in these herbs, however is very small . . . at best . . . a mere 3,000th of the amount found in Prostate Miracle®Advanced Formula.
Beta-sitosterol is also found in common foods we eat every day but in even smaller amounts than the above mentioned herbs. It is completely safe and without any side effects.
The chemical structure of beta-sitosterol is similar to that of cholesterol . . . the main difference being the presence of an extra ethyl group.
When it comes to supporting prostate health, there isn't any natural supplement, that has been studied more extensively than beta sitoterol, which is why it has been a key ingredient in Prostate Miracle® since 2003.
For well over twenty years, the role beta-sitosterol plays in supporting prostate health has been studied extensively. Numerous international scientific journals incuding "European Patent", "European Journal of Drug Metab", "International Journal of Immunopharmacol", "Anticancer Research", "The Lancet", "European Urology", "Minerva Urologia", "British Journal of Clinical Pharmacology", "Medizinische Klinik", "Fortsher Med". and many others, have all published their very impressive findings.Read Less
Not All Beta Sitosterol Is Created Equally.
Beta Sitosterol is found in nearly every vegetable we eat, as well in many herbs such as saw palmetto, stinging nettles, pumpkin seeds etc. However, the concentration in these sources is very low. For over 20 years, extracted beta sitosterol has been used, as a much more potent concentrated source than any of the above mentioned herbs. These days, a wide range of beta sitosterol quality, purity and potency are available.
There is a great deal of confusion, regarding the terms: phytosterols, phytosterol complex, beta sitosterol and beta sitosterol complex. Much of this confusion is propagated by some of new prostate formula companies, who misuse these terms in order to misrepresent their formulas as being "stronger".
In order to intelligently compare "apples to apples", it is important to clarify these terms. To set the record straight . . . Phytosterols (also known as plant sterols) are a group of steroid alcohols, which occur naturally in plants. Included in this group are the sterols: Beta Sitosterol, Campesterol, Stigmasterol, Brasicasterol; as well as the stanols: Campestanol and Stigmastanol. Of all the components in this phytosterol mix, Beta sitosterol is the most important one for supporting prostate health.
It is important to understand that beta sitosterol does not exist as an isolated raw material. Technically speaking the extracted form is always a phytosterol mix (aka a phytosterol complex), of which beta sitosterol is just one component. Sometimes this phytosterol mix is referred to as a beta sitosterol complex, but to describe it as beta sitosterol, is technically inaccurate and somewhat confusing, yet so commonly done in the natural health industry, that even we (with this explanation) use the terms interchangeably on our website.
The amount of beta sitosterol contained in any phytosterol complex, will depend on both the natural balance of the source material as well as the purity of the phytosterols, which is based on the quality and precision of the extraction process.
In previous years, beta sitosterol was often extracted from sugar cane, but today it is most commonly extracted from soy, with a phytosterol purity of up to 95% and typically containing 40-55% beta sitosterol.
The majority of beta sitosterol available in the USA today, is now being imported from China. ALL Chinese made beta sitosterol is extracted from soy. Many of the newer prostate formulas out there, use the cheaper Chinese made beta sitosterol. Ever since the early 1980s, when China first began competing in the raw materials sector of the U.S. nutrition industry, their quality control has come into question. Beta sitosterol and other raw materials exported from China are often contaminated with unacceptable levels of heavy metals or with the residues of herbicides or pesticides.
Chinese beta sitosterol clearly falls far below the standard we will accept for use in Prostate Miracle® Advanced Formula.Read Less
NON GMO Pine Extracted Beta Sitosterol
It turns out that the best source for a high quality beta sitosterol extract is pine. Recent technological advances have led to effective methods for extracting a very pure phytosterol complex from pine, which has a very high concentration of beta sitosterol. It is an expensive process and is not done in the USA, but rather in Europe (where the use of GMO's are banned). Having to import it, makes it an even more expensive raw material. It is however, FAR superior to the Chinese and even the USA produced soy extracts, because not only is it more pure and more potent, but also GMO free as well!
Even amongst the pine extracted phytosterols, there are different qualities available. Prostate Miracle® Advanced Formula uses the highest quality phytosterol complex available. Each daily dosage of Prostate Miracle® provides a 600mg of GMO free, pine based, phytosterol complex (imported from France), guaranteed to be 99% pure and contain NOT less than 70% beta sitosterol.
What is Saw Palmetto?
Saw palmetto (also known as Serenoa Repens) is a low-growing, small palm tree with fanlike, fingery fronds and small berry-shaped fruits. Saw palmetto is native to and grows exclusively in the USA . . . primarily in Florida and near by vicinities.
Saw palmetto berries mainly consist of carbohydrates, phytosterols, fixed oils (free fatty acids and their glycerides), steroids, flavonoids, resin, pigment, tannin, and volatile oil. Native Americans, such as Seminole Indians have been eating saw palmetto fruits for at least 12,000 years. Despite their pungent taste . . . these Indians recognize saw palmetto fruits as both a food and health support.
Prostate Miracle® Advanced Formula contains 3,000 times more beta sitosterol than Saw Palmetto.
Though saw palmetto has been used for centuries, it is important to note that the amount of beta sitosterol contained in saw palmetto is a mere 1/3,000 of the amount contained in one capsule of Prostate Miracle® Advanced Formula. You would have to consume over a pound of saw palmetto berries or over (200) 500 mg capsules of saw palmetto extract to get the equivalent amount of beta sitosterol contained in a single serving of Prostate Miracle® Advanced Formula.
The following exerpt from the ABC news website is based on a study published in the he New England Journal of Medicine (By SIRI E. NILSSON) claims that saw palmetto is ineffective:
- Saw palmetto, an over-the-counter herbal therapy used by more than 2 million men to support prostate health, may be no more effective than a placebo, according to a study published in this week's issue of The New England Journal of Medicine.
- The study followed 225 men who had prostate challenges. Half of the men were given saw palmetto twice a day, and half were given a placebo.
- At the end of one year, the men taking saw palmetto showed no significant improvement compared to the placebo group.
- The findings were welcomed by some doctors who said they felt all along that saw palmetto didn't work. Dr. Jacques Carter, at Beth Israel Deaconess Medical Center in Boston, said he has observed in his own clinical practice that saw palmetto is virtually ineffective. "In nearly every instance, my patients reported little if any improvement of the symptoms on this supplement," Carter said.
- And Dr. Carl Reese, at Pennsylvania State University College of Medicine, hopes the new finding can convince patients to stop wasting money on saw palmetto. "Millions of dollars are spent each year by men on this product and it may not be of any benefit," said Reese. "This article will help the argument that they are wasting their money."
Saw Palmetto and Pygeum Africanum are both worthless.
In a recent article, "natural healing research guru", Roger Mason says "For years now I've been explaining why saw palmetto, pygeum africanum, stinging nettles, pumpkin seeds and other similar herbs are useless, have no therapeutic effect, do not help prostate health in any way and are mere promotional scams. Yet, men keep buying countless millions of dollars worth of saw palmetto and other such worthless products every year.
And all of them are equally worthless because they contain such a low concentration of the supportive ingredient beta sitosterol.
The Beta sitosterol used in Prostate Miracle® Advanced Formula is literally two to three thousand times stronger than saw palmetto powder. This means you would have to eat two to three thousand capsules of saw palmetto powder to get an equivalent amount of beta sitosterol contained in one single capsule of Prostate Miracle® Advanced Formula. What about the extracts, one might ask? The very, very best saw palmetto extracts are only ten to one extractions so you would still need to eat 200 to 300 capsules of saw palmetto extract. Notice what they say on the extract bottles, "contains 85% fatty acids and sterols". This means you get 99% fatty acids and maybe 1% sterols- if you're lucky.
Want proof of how useless saw palmetto and Pygeum africanum are? Here is a typical study published in the Gazzetta Chimica Italiana volume 118 in 1988 (page 823). Some chemists at the University of Milan extracted saw palmetto berries and submitted them to very extensive analysis. Mostly they found common fatty acids like we find in our everyday foods. They found very minor amounts of caratenoids, alcohols, polysaccharides and a tiny, tiny bit of beta-sitosterol complex. In fact they found a mere one part in 5,000 of beta-sitosterols or only one fiftieth of one per cent. This means in this batch of saw palmetto berries you would have to eat 5,000 capsules to get less than 500 mg of beta-sitosterols."Read Less
Saw Palmetto may actually be Harmful to your Prostate.
Three recent scientific studies, surprisingly indicated that saw palmetto may actually harm your prostate health! These studies, which were investigating the effect of saw palmetto on prostate tissue all came to the same conclusion: Saw palmetto has an effect similar to chemotherapy on prostate cells - it kills both unhealthy and healthy cells!
- One study published in Prostate (2000 Nov) examined the effect of saw palmetto on stroma cells (the framework cells that build supportive tissue) and on epithelial cells (those which line the glands and ducts of the prostate). The study was done on normal prostate tissue and on BPH tissues from patients treated with and without the saw palmetto. The conclusion was that saw palmetto damages the nuclear and mitochondrial membranes, and causes cellular death in the epithelium and stroma.
- Another study published in the Journal of Urology (2000 Nov) investigated the effects of saw palmetto on primary cultures of fibroblasts (cells that produce connective tissue), and epithelial cells from the prostate, epididymis (the tube that provides for the storage, transmission and maturation of sperm), testes, kidney, skin and breast to determine if the action of saw palmetto is selective and specific to prostate tissue. This study concluded that saw palmetto caused damage and death in prostate tissue, though there were no similar changes observed in other types of cells.
- A third study published in Prostate (1999 Sep) examined the effect of saw palmetto on benign prostatic hyperplasia (BPH). Again, the results showed there was widespread damage of intracellular membranes, including mitochondrial and nuclear membranes in both healthy and overgrown prostate tissue.
In light of this new information, it seems prudent to avoid saw palmetto. Its toxicity to healthy prostate cells is reason enough to be concerned about taking saw palmetto.Read Less
Lycopene is a Fraud.
Many Prostate Formulas contain lycopene and according to Roger Mason "Lycopene is a fraud, a hoax, a deceit and deception." Nearly every single "study" that has been published on lycopene has simply been a paid advertisement in a journal funded by and paid for by Lyco-Mato in Israel. This isn't science- it is advertising. If lycopene had any value scientists around the world would be using GENERIC lycopene in double blind studies to prove its value.
Research update Feb 2011 The American Association for Cancer Research, just published the results of their latest study of lycopene and prostate cancer prevention and concluded that "Lycopene has no role in prostate cancer prevention." Click here to see the details of their study.
A few years back, there was a published article stating that blood studies of lycopene prove it is effective in treating prostate disease (Pure Appl. Chem. v. 74 in 2002). There were however, serious flaws in the methodology used. It turns out that the researchers measured plasma lycopene levels. The problem with that is that plasma does not carry lycopene. Only the blood serum absorbs the lycopene. Countless, proper serum studies of tens of thousands of men prove beyond any doubt that blood serum lycopene levels are completely unrelated to prostate health in any way, shape or form.
Ohio State University concluded in an extensive review (Pure Appl. Chem. v. 74 in 2002), "The consumption of lycopene supplements is not currently recommended for prostate cancer prevention or therapy".
The famous Hutchison Cancer Center (JNCI v. 92 in 2000) basically concluded lycopene is useless when it comes to prostate health.
Ed Giovannucci has been the biggest supporter of lycopene, but even he admits (Proc. Soc. Exp. Biol. Med. v. 218 in 1998), "However, it is premature to suggest that either tomatoes or lycopene is causally related to protection from prostate cancer or that the consumption of products rich in lycopene will have a beneficial effect for men suffering from established prostate cancer."
The Japan-Hawaii Cancer Center (Cancer Epidem. Biol. Prev. 6 in 1997) studied serum from 6,680 men and found it unrelated to prostate health.
The biggest of all studies from NIH and Johns Hopkins University (JNCI v.82 in 1990) studied the serum of 25,802 men and found no relation whatsoever with prostate health and lycopene levels.
We could go on all day with such studies to prove the lycopene is a useless promotion for profit but you get the idea by now.Read Less
Selenium and Prostate Health
When was the last time your doctor suggested that you supplement with selenium in an effort to prevent cancer?
Probably never . . . But did you know that researchers have been studying the plausibility of such a suggestion?
Scientists know that this trace mineral has some extraordinary properties and have been aggressively investigating it's health supporting potential. Research is currently being conducted to see if selenium might have any impact on the risk of getting prostate cancers and other conditions involving oxidative stress and inflammation.
Doctors assume that we get enough selenium through plant foods. Unfortunately, in many places in America and the rest of the world, including China and Russia, the soil is badly depleted of its selenium content because of acid rain, which can dramatically change the chemical composition of the soil. As a result, soil acidification alters the ability of the soil to bind with vital elements such as selenium for assimilation into edible plants.
Selenium has unique biochemical properties
What makes selenium unique? While scientists are still studying selenium’s role in a multitude of biochemical processes, one of its chief attributes is serving as a component of specific proteins called selenoproteins. Almost all of these proteins are active in the scavenging of free radicals.
Selenium is the only mineral nutrient that has its own DNA code, which instructs the body’s protein-synthesis “machinery” to incorporate selenium into its host proteins. Scientists interpret this unique attribute as evidence of selenium’s fundamental importance to virtually all living things on Earth.
Selenium is available from many dietary sources, including garlic, Brazil nuts, and certain vegetables; however, the amount of bioavailable selenium from these sources varies tremendously, depending on the soil and weather conditions where the plants are grown. Furthermore, many foods containing selenium also contain substances that limit selenium’s bioavailability. Therefore, selenium supplementation is often recommended as a way to assure a dependable, bioavailable supply of this nutrient.
As scientists continue to discover the many ways in which oxidative stress is related to inflammation and its destructive consequences—from atherosclerosis to prostate, lung, colon, and other cancers, trace minerals such as selenium are likely to be the subject of even more research.Read Less
Selenium Chelates versus Selenium Glycinate Complex
There is a great deal of confusion regarding selenium chelation. Many raw material suppliers provide, what they call a "selenium amino acid chelate", but that term is actually a misnomer. In order to clarify this often misunderstood subject, it is first necessary to understand chelation in general.
Most minerals are somewhat un-bioavailable because they typically carry a charge. This charge relates to the valance or state of free electrons in the outer shell of the mineral's atomic structure.
Regardless of whether the mineral is in the form of a salt or is in an ionic state, if it has a charge . . . it will have difficulty passing through cell membranes (where it is needed by the cells). This difficulty is due to interference from the charge of the cell membrane, which like the charge of a magnet, will either repel the same charge or attract the opposite charge. In either case, the charged minerals's ability to pass through the cell membrane will be impeded resulting in less than optimal bioavailability.
Chelation is a technique sometimes deployed to improve the bioavailability of these charged minerals. The idea is to wrap an amino acid molecule around the mineral so that it will bind to the mineral in two spots, resulting in a neutral, stable, chelated mineral, which can then pass through the cell membrane much easier than it's ionic or salt counterpart.
Chelation occurs when unpaired electrons become non-ionically bound to the electron deficient environment of the positively charged central ion. EVERY amino acid (including glycine) has both a carbonyl end and an amine end. Though, neither end functions as a "negative group", both ends have a set of unpaired electrons. Thus ALL amino acids can form coordinate complexes in two places making them ideal chelating agents.
Selenium has six valance electrons and typically carries a -2 charge. Furthermore, because it's outer shell is lacking only two electrons from having a closed shell configuration, it wants to receive a pair of electrons in order to complete it's shell. Once the shell is complete however, it is not possible to transfer another pair of electrons to it.
For this reason, it is physically impossible for any chelating agen such as glycine (or any other amino acid) to bond with a selenium ion in two sites, so by definition, selenium can not be chelated. In other words, there is no such thing as a selenium chelate.
None of those so called "selenium amino acid chelates" are actually chelates at all. They are typically just a selenium salt combined with a hydrolyzed vegetable protein, having a bioavailability that is not any greater than just the selenium salt or selenium ion.
It turns out that the best way to improve the bioavailability of selenium is to bond it to glycine (an amino acid), resulting in a selenium glycinate complex, which although not neutral, has a -1 charge, and as a result has a much easier time passing through a cell membrane than do mineral salts, ions or any of the so called "selenium chelates".
The selenium we use in Prostate Miracle® Advanced Formula is Albion® Selenium Glycinate Complex, made by Albion Laboratories, Inc., an industry leader in manufacturing chelated minerals since the 1950's. If there was a way to chelate selenium, they would certainly be producing it, but because it is not possible (due to the atomic structure of selenium), they produce the next best thing, which is Albion® Selenium Glycinate Complex.
It is worth noting that, the glycine used in producing Albion® Selenium Glycinate Complex is NOT derived from any GMO source. I am unaware of any prostate support formula out there (other than Prostate Miracle® Advanced Formula) that uses Albion® Selenium Glycinate Complex as it's source of selenium. Even if all of the other ingredients in a formula are derived from non GMO sources, if it contains one of those so called "selenium amino acid chelates", it is not likely that a legitimate "all non GMO ingredients" label claim can be made.
A daily serving of Prostate Miracle® Advanced Formula provides 70 mcg of non GMO Albion® Selenium Glycinate Complex, which is an optimal amount to support prostate health.Read Less
Zinc and Prostate Health
The concentration of zinc in the prostate is higher than that in ANY other soft tissue in the body. This naturally occurring high concentration suggests that zinc may play a role in prostate health.
It is well known that neoplastic diseases, inflammatory diseases, infections and other stresses lead to changes in zinc metabolism, which results in lower blood serum zinc levels in general and lower zinc prostate levels in particular.
- Men with prostatitis typically have 90% lower zinc levels in their prostate than men without prostatitis.
- Men with prostate cancer typically have 83% lower zinc levels in their prostate than men without prostate cancer.
- Men with BPH typically have 61% lower zinc levels in their prostate than men without BPH.
A growing body of evidence supports the notion that high zinc levels are essential for prostate health. The possible mechanisms include the effects of zinc on the inhibition of terminal oxidation, induction of mitochondrial apoptogenesis and suppression of NF-kappaB activity. Zinc may also play an important role in the maintenance of DNA integrity in normal prostate epithelial cells by modulating DNA repair of damaged response proteins, especially p53. In addition, recent findings support the role of the ZIP1 zinc transporter protein, as a tumor suppressor in the prostate.
It is well documented that tumor cells undergo metabolic transformations, that are essential for their malignant existence, but are not the cause of malignancy. The specialized function of the normal prostate glandular epithelium (to produce and secrete enormously high levels of citrate) requires unique intermediary metabolic activities, that are not generally associated with other normal mammalian cells.
The accumulation of zinc in normal prostate glandular epithelial cells results in two important effects, a metabolic effect, and a proliferative effect. Its metabolic effect is the inhibition of citrate oxidation, which is necessary for prostate function. A second effect of zinc is its inhibition on prostate-cell proliferation.
In malignancy, the normal zinc-accumulating citrate-producing epithelial cells are metabolically transformed to citrate-oxidizing cells that lose the ability to accumulate zinc. A genetic alteration in the expression of ZIP1 zinc transporter is associated with this metabolic transformation. These genetic/metabolic relationships have important consequences on citrate-related metabolism, bioenergetics, cell proliferation, and invasive capabilities of the malignant cells, which result in tumor-suppression characteristics. Zinc is critical to these relationships.
It appears that the development of malignancy in prostate cancer may involve an essential metabolic transformation that results in the lost capability of malignant cells to accumulate zinc. Consideration of the clinical and biochemical evidence presented here leads to the conclusion that an altered zinc metabolism may play an important role in the pathogenesis of prostate malignancy.
Further studies will help clarify whether, along with clinical diagnosis, the zinc concentration in prostate biopsy specimens, plasma zinc and urine zinc/creatinine ratio of patients presenting with symptoms of prostatic diseases, are useful in the differential diagnosis of diagnosed prostatic carcinoma and BPH.
Dietary Sources of Zinc
Zinc is found in a wide variety of foods, including red meat and poultry. Other good food sources include beans, nuts, certain seafood, whole grains, fortified breakfast cereals, and dairy products. Zinc absorption is greater from a diet high in animal protein than a diet rich in plant proteins.
Can Too Much Zinc Increase Your Risk of Prostate Cancer?
in 2003, a study published in the Journal of the National Cancer Institute, theorized that taking too much zinc can actually increase the risk of getting prostate cancer. Though this study has not been duplicated nor was any explanation given, the main finding was that men who consumed more than 100 mg/day of zinc were 2.29 times more likely to develop advanced prostate cancer than men whose total zinc intake was less than 100 mg/day. Men whose zinc supplementation was 100 mg/day or less were not at increased risk for any kind of prostate cancer
As scientists continue to discover the many ways in which oxidative stress is related to inflammation and its destructive consequences—from atherosclerosis to prostate, lung, colon, and other cancers, trace minerals such as selenium are likely to be the subject of even more research.
A daily serving of Prostate Miracle® Advanced Formula provides 15 mg of zinc, which is an optimal amount to support prostate health.Read Less
Vitamin D3 and Prostate Health
A new study published by the journal Clinical Cancer Research (May 2014), suggests that low blood levels of vitamin D may be linked to more aggressive and advanced cases of prostate cancer. The study suggests that vitamin D may play an important role in how prostate cancer starts and spreads, although it does not prove a cause-and-effect relationship. Researchers aren't yet sure exactly how it comes into play or even if taking extra vitamin D might keep prostate cancer in check.
"We really don't know, for certain, what role vitamin D plays in cancer . . . either the genesis or beginning of cancer . . . or in defining how aggressive the cancer may be," he said. "Further research has to be done."
What is known is that vitamin D plays several critical roles in how cells develop and grow.
"It seems to regulate normal differentiation of cells as they change from stem cells to adult cells. And it regulates the growth rate of normal cells and cancer cells." said study author Dr. Adam Murphy, an assistant professor of urology at Northwestern University's Feinberg School of Medicine, in Chicago.
Vitamin D is also known as the "sunshine vitamin" because skin makes it when exposed to sunlight. Vitamin D levels tend to drop with advancing age, and deficiency is more common in seasons and regions that get less sunlight and in people with darker skin, which naturally blocks the sun.
What about the vitamin's possible relationship to cancer?
"When you squirt vitamin D on prostate cells in a petri dish, their rate of growth slows down," Murphy said.
The idea is that too little of this critical vitamin in the body may cause cell growth to go awry, leading to cancer.
To test that idea, researchers checked vitamin D levels in 667 Chicago men between the ages of 40 and 79 who were having prostate biopsies because they'd recently had an abnormal prostate specific antigen (PSA) test or because a doctor felt changes to the prostate during a physical exam.
- Normal vitamin D levels are in the range of 30 to 80 nanograms per milliliter (ng/ml).
- Vitamin D deficiency, or a level under 20 ng/ml, was relatively common among all the men tested.
- About 44 percent of the men with positive biopsies and 38 percent of those who tested negative for cancer had low vitamin D levels.
- Among men who tested positive for cancer after their biopsies, those who also had very low levels of vitamin D under 12 ng/ml had greater odds of more advanced and aggressive cancers than those with normal levels.
The connection between vitamin D and cancer seemed to be even stronger in black men.
- Black men with vitamin D levels under 12 ng/ml were far more likely than those with normal levels to test positive for prostate cancer in the first place.
- In general, black men are also more likely to be diagnosed with prostate cancer. On average, men have about a one-in-seven lifetime risk of getting prostate cancer. That risk rises to one in five for black men, according to the U.S. Centers for Disease Control and Prevention.
- Researchers aren't sure whether lower vitamin D levels may help to explain why black men are at higher risk for prostate cancer. They say longer and larger studies are needed to sort out the connection.
A University of Colorado Cancer Center study published in the journal Prostate (2014) looked at the possibility that vitamin D may help reduce cancer-causing inflammation. Scientists found that the gene GDF-15, known to be up-regulated by vitamin D can help block a protein which stimulates tumor growth.
"When you take vitamin D and put it on prostate cancer cells, it inhibits their growth. But it hasn't been proven as an anti-cancer agent" said James Lambert, lead investigator at the University of Colorado Cancer Center. "We wanted to understand what genes vitamin D is turning on or off in prostate cancer to offer new targets."
Using a sophisticated computer algorithm, researchers analyzed samples of prostate cells and compared them to the prevalence of GDF-15 and inflammatory cells. Because they were able to demonstrate that vitamin D up-regulates the gene expression for GDF-15, they decided to further investigate to see if GDF-15 could be a pathway in which vitamin D inhibits prostate tumor growth. The results were compelling.
"There's been a lot of work on inhibiting NFkB," said Lambert. "Now, from this starting point of vitamin D in prostate cancer, we've come a long way toward understanding how we might use GDF-15 to target NFkB, which may have implications in cancer types far beyond prostate."
Have you checked your vitamin D blood level lately? If not, you may want to make an appointment with your doctor to check them with a simple blood test. Your levels should be between 30 and 80 ng/mL.
If you are thinking about taking a vitamin D supplement, you should be taking at least 1,000-2,000 IU a day,
A daily serving of Prostate Miracle® Advanced Formula provides 2,000 IU of vitamin D3, which is an optimal amount to support prostate health.Read Less
The Prostate Miracle® Difference
- Each capsule of Prostate Miracle®Advanced Formula contains: a whopping 300 mg of Beta-Sitosterol, 7.5 mg of Zinc, 35 mcg of Selenium and 1,000 iu's of Vitamin D3.
- Each bottle of Prostate Miracle® Advanced Formula contains 60 vegetable capsules . . . providing 18,000 mg of Beta Sitosterol per bottle.
- Prostate Miracle® Advanced Formula contains the highest quality Beta Sitosterol available. The suggested daily dosage provides 600 mg of GMO free, pine based, phytosterol complex (imported from France),guaranteed to be 99% pure and contain NOT less than 70% beta sitosterol.
- Prostate Miracle® Advanced Formula is produced in GMP certified labs (in the USA) and distributed by Nature's Health Supply, Inc.® (a company trusted by hundreds of thousands since 2001).
- When you consider that Prostate Miracle® Advanced Formula is priced lower than most of these others . . .There is just no other product that comes close to it's quality and value!
Prostate Miracle® Advanced Formula
has a Money Back Guarantee
Look at any other Prostate Formula out there and ask yourself:
How much Beta Sitosterol does it contain per capsule?
What is the purity and potency of the ingredients?
How many capsules does each bottle contain?
How much Beta Sitosterol does it contain per bottle?
What is the cost per bottle?
Once you have done the math . . . you will know that there is no other product that comes close in comparison to the long term prostate support, safety and value of Prostate Miracle® Advanced Formula.
We Guarantee it!!
Prostate Miracle® Advanced Formula offers this guarantee:
We guarantee that within 60 days (two bottles), Prostate Miracle® Advanced Formula will provide significant support for the health of your prostate. If it does not . . . just send the two empty bottles back and we will issue a 100% refund (less the cost of shipping).
Prostate Miracle® Advanced Formula
60 capsules per bottle
(30 day supply)
- Beta Sitosterol
- Zinc (7.5 mg/capsule)
- Selenium (35 mcg/capsule)
- Vitamin D3 (1,000 iu's/capsule)
1 capsule twice per day
- 1 bottle
- 2 bottles $25.95 each
- 3 bottles $22.95 each
Prostate Miracle Advanced Formula® Supplement Facts
|Serving Size: 1 Capsule
Capsules per container: 60
Servings per container: 60
|Amount per 2 Servings||% Daily Value|
(from non GMO Pine)
|Vitamin D3 (as cholecalciferol)||2,000 iu's||500%|
|Zinc (as Zinc Citrate)||15 mg||100%|
|Selenium (as Albion® Selenium Glycinate Complex)||70 mcg||100%|
*Daily value not established.
Other ingredients: 100% Vegetable capsule, L-Leucine
Take one capsule in the morning and one in the evening.
Two other Products for Additional Support of Prostate Health:
Pectin Plus® is a great Companion product to Prostate Miracle®
- Supports Healthy Detoxification
- Supports Healthy Cholesterol
- Supports Cardiovascular Health
- Promotes Healthy Blood Pressure
- Promotes Healthy Cell Growth
- Promotes Healthy Immune Response
180 capsules per bottle (30 day supply)
- Citrus Pectin (500 mg/capsule)
- Odorless Garlic extract (100 mg/capsule)
- Cilantro extract (10:1) (50 mg/capsule)
3 capsules twice per day
Click Here for more info.
- 1 bottle - Pectin Plus
- 2 bottles - Pectin Plus $28.95 each
- 3 bottles - Pectin Plus $27.95 each
- 6 bottles - Pectin Plus $26.95 each
Estrogen Balance™ is a great Companion product to Prostate Miracle®
- Supports Healthy Estrogen
- In Men:
- Promotes Prostate Health
- In Women:
- Promotes Breast and Uterine Health
- In Men and Women:
- Promotes Cardiovascular health
60 capsules per bottle (30 day supply)
- Quercetin (125 mg per capsule)
(100 mg per capsule)
- Flax Seed
(450 mg per capsule)
1 capsule twice per day
Click Here for more info.
- 1 bottle - Estrogen Balance
- 2 bottles - Estrogen Balance $25.95 each
- 3 bottles - Estrogen Balance $24.95 each
- 6 bottles - Estrogen Balance $23.95 each
Prostate Duo Pack
- 1 of each
- 2 of each $49.48 per duo
- 3 of each $45.32 per duo
Prostate Trio Pack
- 1 of each
- 2 of each $77.48 per trio
- 3 of each $72.65 per trio
Other Products Available from: NHS Global Distributors, Inc.
Supports healthy detoxification, healthy blood pressure, healthy cholesterol levels and prostate healthread more
A natural formula for Men & Women, combining: D.I.M., Quercetin and Flaxseed.read more
A Whole-Superfood supplement, combining an optimal blend of sea vegetables and Freshwater algae.read more
An immune system support formula based on Beta Glutan, which is unsurpassed in it's ability to help support a healthy immune response.read more
Each bottle contains 2 fl oz of Full Spectrum Hemp Extract OIl, made from organic hemp buds (not seeds), using supercritical CO2 extraction.read more
P.O. Box 271
Camarillo, CA 93011-0271
Thank you for visiting Prostate-Miracle.com
This information here within is designed to provide accurate information in regard to the subject matter covered. It is provided with the understanding that NHS Global Distributors, Inc. is not engaged in rendering medical advice. If expert assistance is required, the services of a competent medical professional should be sought. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Always read and follow manufacturer's directions that come with this product.
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